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. 2014 Oct 18;50(81):12150-3.
doi: 10.1039/c4cc05867d.

Chemical modification of temoporfin--a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

Q Yu  1 , E M Rodriguez, R Naccache, P Forgione, G Lamoureux, F Sanz-Rodriguez, D Scheglmann, J A Capobianco
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Free article

Chemical modification of temoporfin--a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

Q Yu et al. Chem Commun (Camb). .
Free article

Abstract

LiYF4:Tm(3+)/Yb(3+) upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation.

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