The deep penetrating nevus

Abstract

The deep penetrating nevus (DPN), also known as the plexiform spindle cell nevus, is a pigmented lesion that commonly arises on the head and neck in the first few decades of life. Histopathologically, the DPN is wedge-shaped and contains melanocytes that exhibit deep infiltration into the dermis. Given these features, DPN may clinically and histopathologically mimic malignant melanoma, sparking confusion about the appropriate evaluation and management of these lesions. The goal of this review is to summarize the clinical and histopathological features of DPN and to discuss diagnostic and treatment strategies for dermatologists.

Keywords: deep penetrating nevus; dermatopathology; malignant melanoma; melanocytic tumor of uncertain malignant potential; nevus with focal atypical epithelioid components; plexiform spindle cell nevus.