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Case Reports
. 2014 Sep;23(133):390-2.
doi: 10.1183/09059180.00009313.

Germ-line exon 21 EGFR mutations, V843I and P848L, in nonsmall cell lung cancer patients

Nathalie Prim  1 , Michele Legrain  2 , Eric Guerin  1 , Bertrand Mennecier  2 , Noelle Weingertner  2 , Anne-Claire Voegeli  2 , Dominique Guenot  2 , Christine M Maugard  2 , Anne-Elisabeth Quoix  2 , Michele Beau-Faller  3
Affiliations
Case Reports

Germ-line exon 21 EGFR mutations, V843I and P848L, in nonsmall cell lung cancer patients

Nathalie Prim et al. Eur Respir Rev. 2014 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: Disclosures can be found alongside the online version of this article at err.ersjournals.com

Figures

Figure 1.
Figure 1.
a–c) Case 1, with epidermal growth factor receptor (EGFR) exon 21 mutations (V843I and L858R). a) Pedigree chart. The black case corresponds to the index patient. b) DNA sequencing electrophoretograms for DNA obtained from lung tumour tissue identifying EGFR exon 21 mutations; both mutations are present. c) DNA sequencing electrophoretograms for DNA obtained from blood, identifying one EGFR exon 21 mutation, the V834I variant, is present and confirming it is germ-line. d–f) Case 2, with EGFR exon 21 mutation (P848L). d) Pedigree chart. The black case corresponds to the index patient. The hatched box represents a case with head and neck carcinoma. e) DNA sequencing electrophoretograms for DNA obtained from lung tumour tissue identifying an EGFR exon 21 mutation (P848L). f) DNA sequencing electrophoretograms for DNA obtained from blood identifying the EGFR exon 21 P848L variant is present and confirming it is germ-line.
See this image and copyright information in PMC

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