Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Sep;6(5):422-6.
doi: 10.1177/1941738114539911.

Viscosupplementation during rehabilitation

Affiliations

Viscosupplementation during rehabilitation

Holly J Silvers. Sports Health. 2014 Sep.

Abstract

Context: Viscosupplementation (VS) and physical therapy are both used to treat pain associated with knee osteoarthritis (OA).

Evidence acquisition: PubMed and EMBASE searches were performed to July 2013. Search terms included hyaluronic acid OR hylan, physical therapy OR exercise, AND osteoarthritis.

Study design: Clinical review.

Level of evidence: Level 4.

Results: The efficacy and safety of VS in painful knee OA is well documented, as are the appropriate candidates for this intervention. Studies suggest that adding VS to physical therapy and therapeutic exercise may lead to improved pain reduction and increased functionality compared with physical therapy alone.

Conclusion: Appropriately selected patients undergoing physical therapy for knee OA may benefit from VS.

Keywords: anterior cruciate ligament surgery; hyaluronic acid; knee osteoarthritis; physical therapy; viscosupplementation.

PubMed Disclaimer

Conflict of interest statement

The author declared potential conflicts of interest: Sanofi provided financial support to Precise Publications to assist in the writing of this article.

References

    1. Altman RD, Moskowitz R. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group. J Rheumatol. 1998;25:2203-2212 - PubMed
    1. Altman RD, Rosen JE, Bloch DA, Hatoum HT. Safety and efficacy of retreatment with a bioengineered hyaluronate for painful osteoarthritis of the knee: results of the open-label Extension Study of the FLEXX Trial. Osteoarthritis Cartilage. 2011;19:1169-1175 - PubMed
    1. Altman RD, Rosen JE, Bloch DA, Hatoum HT, Korner P. A double-blind, randomized, saline-controlled study of the efficacy and safety of EUFLEXXA for treatment of painful osteoarthritis of the knee, with an open-label safety extension (the FLEXX trial). Semin Arthritis Rheum. 2009;39:1-9 - PubMed
    1. Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA. Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association. Circulation. 2007;115:1634-1642 - PubMed
    1. Arnold W, Fullerton DS, Holder S, May CS. Viscosupplementation: managed care issues for osteoarthritis of the knee. J Manag Care Pharm. 2007;13:3-19 - PMC - PubMed