Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2014 Jul;8(7):FD09-10.
doi: 10.7860/JCDR/2014/9112.4578. Epub 2014 Jul 20.

Acute myeloid leukemia presenting as "bowel upset": a case report

Smeeta Gajendra  1 , Ajay Gogia  2 , Prasenjit Das  3 , Ritu Gupta  4 , Pranay Tanwar  5
Affiliations
Case Reports

Acute myeloid leukemia presenting as "bowel upset": a case report

Smeeta Gajendra et al. J Clin Diagn Res. 2014 Jul.

Abstract

Myeloid sarcomas (MS) are the extramedullary presentation of acute myeloid leukemias. At times, they are difficult to diagnose due to lack of any supportive findings in peripheral blood/bone marrow aspirate examination. The involvement of gastrointestinal tract (GIT) by myeloid sarcoma is rare phenomenon. This diagnostic challenge becomes more complex when it is added by vague clinical symptoms. Many times, they have been misdiagnosed as Non-Hodgkin's lymphoma, small round cell tumour or carcinoma. Here, we are reporting a case of myeloid sarcoma with no haematological abnormality which presented with the symptoms of bowel obstruction and a rare combination of inv. (16) and trisomy 22. The journey to reach the conclusive diagnosis in this case is interesting and sensitizes us to have high index of suspicion in a case, where there is paucity of clinical evidences.

Keywords: Acute myeloid leukemia; Blast; Intussusception; Lymphadenopathy; Myeloid sarcomas.

PubMed Disclaimer

Figures

[Table/Fig-a-d]:
[Table/Fig-a-d]:
Photomicrograph shows bone marrow aspirate with blast and auer rod (insat) [(1A), Jenner and Giemsa, x100)]. Section from small intestinal wall with diffuse transmural infiltration by a population of discretely lying tumor cells which are infiltrating the mucosal glands. A few eosinophils are also seen [(1B), H&E x100]. These tumor cells are strongly positive or CD34 stain [(1C), IHC (CD34) x100] and Myeloperoxidase stain [(1D), IHC (MPO) x100]
See this image and copyright information in PMC

References

    1. M Breccia, F Mandelli, MC Petti, M D’Andrea, E Pescarmona, SA Pileri, et al. Clinico-pathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution. Leuk Res. 2004;28(11):1165–69. - PubMed
    1. Kohl SK, Aoun P. Granulocytic sarcoma of the small intestine. Archives of Pathology and Laboratory Medicine. 2006;130(10):1570–74. - PubMed
    1. EK Choi, HK Ha, SH Park, SH Lee, SE Jung, KW Kim, et al. Granulocytic sarcoma of bowel: CT findings. Radiology. 2007;243(3):752–59. - PubMed
    1. MM Le Beau, RA Larson, MA Bitter, JW Vardiman, HM Golomb, JD Rowley. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. N Engl J Med. 1983;309:630–36. - PubMed
    1. SL Russell, FJ Giles, DS Thompson, DJ Scanlon, H Walker, JDM Richards. Granulocytic sarcoma of the small intestine preceding acute myelomonocytic leukemia with abnormal eosinophils and inv (16). Cancer Genet Cytogenet. 1988;35:231–35. - PubMed

Publication types

LinkOut - more resources