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Case Reports
. 2014 Jul;8(7):OD12-3.
doi: 10.7860/JCDR/2014/8274.4645. Epub 2014 Jul 20.

Chemoresistant gestational trophoblastic neoplasia: a case report

Sudha Cp  1 , Sahana M  2
Affiliations
Case Reports

Chemoresistant gestational trophoblastic neoplasia: a case report

Sudha Cp et al. J Clin Diagn Res. 2014 Jul.

Abstract

Gestational trophoblastic neoplasia (GTN) is a disease of women in reproductive age. It is one of the most chemotherapy responsive and highly curable cancer. It is diagnosed when there is clinical, radiologic, pathologic, and/or hormonal evidence of persistent or relapsed gestational trophoblastic disease. In most instances, it is cured by surgical evacuation of the uterus. If persistent, it is treated with chemotherapy which provides response in >90% of the cases. In the unresponsive persistent cases and if the women has completed her child bearing, hysterectomy is generally recommended. Here, we report a rare case of chemoresistant GTN which was confirmed to be placental-site trophoblastic tumour (PSTT) on biopsy.

Keywords: GTN; Placental site trophoblastic tumour; Uterine tumour.

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Figures

[Table/Fig-1]:
[Table/Fig-1]:
Ultrasound guided scan shows well-defined hyperechoic lesion measuring 2.5 * 2.2*2 cm with few areas of heteroechogenecity in the center, the endometrium is splayed around the mass
[Table/Fig-2]:
[Table/Fig-2]:
Changes in β hCG levels (mIU/ml) during the treatment period
[Table/Fig-3]:
[Table/Fig-3]:
Microscopic pictures with 40x magnification and hematoxylin and eosin stain of section piece of mass showing large areas of hemorrhage and tumour cells infiltrating the 1/3rd of myometrium
[Table/Fig-4]:
[Table/Fig-4]:
Microscopic pictures with 400x magnification and hematoxylin and eosin stained tumour cells are arranged in sheets and groups, individual cells are large pleomorphic with abundant eosinophillic cytoplasmic pleomorphic vesicular nuclei
See this image and copyright information in PMC

References

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