Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:182596.
doi: 10.1155/2014/182596. Epub 2014 Aug 10.

An analysis of the Malassezia species distribution in the skin of patients with pityriasis versicolor in Chengdu, China

Zhen Xie  1 , Yuping Ran  2 , Hao Zhang  2 , Min Zhang  3 , Huiying Wan  2 , Conghui Li  2
Affiliations

An analysis of the Malassezia species distribution in the skin of patients with pityriasis versicolor in Chengdu, China

Zhen Xie et al. ScientificWorldJournal. 2014.

Abstract

Pityriasis versicolor (PV) is a common clinical problem associated with Malassezia species (Malassezia spp.). Controversies remain regarding the specific species involved in the development of PV. This study analyzed the difference in Malassezia spp. distribution in lesional and nonlesional skin in Chinese PV patients. A paired design was applied. Lesional and nonlesional scales from 24 cases were collected; real-time fluorescence quantitative PCR was used to detect 10 different Malassezia spp. In lesional skin, the highest detection rates were for M. globosa (95.8%), M. restricta (91.7%), and M. sympodialis (50.0%). In nonlesional skin, the highest detection rates were for M. globosa (87.5%), M. restricta (79.2%), and M. dermatis (33.3%). A significant difference in the detection rate was only found for M. sympodialis (50.8% versus 20.8%, P = 0.04). Compared with nonlesional skin, the amount of M. globosa, M. restricta, and M. sympodialis in lesional skin was significantly higher (3.8 ± 1.3, 2.5 ± 1.1, and 3.2 ± 1.6 times higher, resp.). The results of this study do not indicate that M. globosa and M. restricta are directly correlated with PV development; however, M. sympodialis is more likely related to PV development in Chinese individuals.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Electropherogram of the lesional and nonlesional skin DNA samples from patients 1–8 after ITS1/ITS4 amplification. The lanes of the lesional scales are coded as the patient number + L (lesion), and the lanes of the nonlesional skin samples are coded as the patient number + N (normal). M signifies the marker, and NC signifies the negative control. Positive bands appeared at the 600–800 bp position in each sample lane. No band appeared in the NC.
Figure 2
Figure 2
Malassezia species detection rates in the lesional and nonlesional skin of the 24 patients. ∗P < 0.05, nonlesional skin versus lesional skin.
Figure 3
Figure 3
The relative quantity of each Malassezia species in the lesions compared with the nonlesional skin of the 24 patients. The y-axis displays the increased prevalence of the species in the lesions compared with the nonlesional skin. ∗P < 0.05, nonlesional skin versus lesional skin.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Gandra RF, Gambale W, De Cássia Garcia Simão R, et al. Malassezia spp. in acoustic meatus of bats (Molossus molossus) of the Amazon region, Brazil. Mycopathologia. 2008;165(1):21–26. - PubMed
    1. Lai X, Cao L, Tan H, Fang S, Huang Y, Zhou S. Fungal communities from methane hydrate-bearing deep-sea marine sediments in South China Sea. ISME Journal. 2007;1(8):756–762. - PubMed
    1. Dankner WM, Spector SA, Fierer J, Davis CE. Malassezia fungemia in neonates and adults: complication of hyperalimentation. Reviews of Infectious Diseases. 1987;9(4):743–753. - PubMed
    1. Larocco M, Dorenbaum A, Robinson A, Pickering LK. Recovery of Malassezia pachydermatis from eight infants in a neonatal intensive care nursery. The Pediatric Infectious Disease Journal. 1988;7(6):398–401. - PubMed
    1. Mickelsen PA, Viano-Paulson MC, Stevens DA, Diaz PS. Clinical and microbiological featurs of infection with Malassezia pachydermatis in high-risk infants. Journal of Infectious Diseases. 1988;157(6):1163–1168. - PubMed

Publication types

LinkOut - more resources