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Case Reports
. 2014 Sep 1:2014:bcr2014204769.
doi: 10.1136/bcr-2014-204769.

Paediatric selective IgM deficiency and IgG4 deficiency: an extremely unusual association

Rishi Bolia  1 , Durga Prasanna Misra  2 , Amita Aggarwal  2 , Anshu Srivastava  1
Affiliations
Case Reports

Paediatric selective IgM deficiency and IgG4 deficiency: an extremely unusual association

Rishi Bolia et al. BMJ Case Rep. .

Abstract

Humoral immunodeficiency disorders present in children after 6 months of age with recurrent respiratory and gastrointestinal infections. These may be due to the absence of B cells causing panhypogammaglobulinaemia, or due to selective deficiencies in immunoglobulin subfractions. We present the case of a child with selective deficiency of IgM and IgG4 resulting in chronic diarrhoea and recurrent lower respiratory infections. With appropriate treatment of infections, the child had good symptom relief. Such an unusual combination of antibody deficiency has not been previously described in children. This case serves to illustrate the need for awareness to institute timely therapy for infection along with appropriate prophylactic measures like vaccination for these children.

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References

    1. Driessen G, van der Burg M. Educational paper: primary antibody deficiencies. Eur J Pediatr 2011;170:693–702 - PMC - PubMed
    1. Ideura G, Agematsu K, Komatsu Y, et al. Selective IgM deficiency accompanied with IgG4 deficiency, dermal complications and a bronchial polyp. Allergol Int 2008;57:99–105 - PubMed
    1. Goldstein MF, Goldstein AL, Dunsky EH, et al. Pediatric selective IgM immunodeficiency. Clin Dev Immunol 2008;2008:624850. - PMC - PubMed
    1. Louis AG, Gupta S. Primary selective IgM deficiency: an ignored immunodeficiency. Clin Rev Allergy Immunol 2014;46:104–11 - PubMed
    1. Heiner DC, Myers A, Beck CS. Deficiency of IgG4: a disorder associated with frequent infections and bronchiectasis that may be familial. Clin Rev Allergy 1983;1:259–66 - PubMed

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