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Review
. 2015 Jun;9(2):293-9.
doi: 10.1007/s12105-014-0564-2. Epub 2014 Sep 2.

Dedifferentiated salivary hybrid carcinoma of the maxillary sinus with pagetoid spread to the overlying lining mucosa

Tien Anh N Tran  1 , Timothy Jennings, J Andrew Carlson
Affiliations
Review

Dedifferentiated salivary hybrid carcinoma of the maxillary sinus with pagetoid spread to the overlying lining mucosa

Tien Anh N Tran et al. Head Neck Pathol. 2015 Jun.
No abstract available

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Figures

Fig. 1
Fig. 1
a–f Salivary hybrid carcinoma composed of adenoid-cystic carcinoma (a) and epithelial-myoepithelial carcinoma (b) with foci of high-grade transformation (c). High-grade transformed neoplastic cells expand a secretory duct opening to the surface epithelium (d) leading to pagetoid spread of tumor cells in the lining mucosa (e). Bone invasion by high-grade adenocarcinoma in the re-excision (f)
Fig. 2
Fig. 2
a–f Immunohistochemical studies display a layer of p53 positive myoepithelial cells at the periphery of the nests of transformed neoplastic cells (a). There is a significantly higher expression of Ki-67 (b) and p53 in the high grade component (c) compared to the adenoid-cystic carcinoma (d, e). Focal Her2-neu immunopositivity in the high-grade component (f) whereas the low grade adenoid-cystic carcinoma is completely negative (not shown)
See this image and copyright information in PMC

References

    1. Seifert G G, Donath K. Hybrid tumours of salivary glands. Definition and classification of five rare cases. Eur J Cancer Part B Oral Oncol. 1996;32B(4):251–259. doi: 10.1016/0964-1955(95)00059-3. - DOI - PubMed
    1. Ellis G, Auclair P, Gnepp D, editors. Surgical pathology of the salivary glands. Philadelphia: Saunders; 1991.
    1. Delgado R, Klimstra D, Albores-Saavedra J. Low grade salivary duct carcinoma. A distinctive variant with a low grade histology and a predominant intraductal growth pattern. Cancer. 1996;78(5):958–967. doi: 10.1002/(SICI)1097-0142(19960901)78:5<958::AID-CNCR4>3.0.CO;2-8. - DOI - PubMed
    1. Ballestin C, Lopez-Carreira M, Lopez JI. Combined acinic cell mucoepidermoid carcinoma of the parotid gland. Report of a case with immunohistochemical study. APMIS. 1996;104(2):99–102. doi: 10.1111/j.1699-0463.1996.tb00693.x. - DOI - PubMed
    1. Kamio N, Tanaka Y, Mukai M, Ikeda E, Kuramochi S, Fujii M, et al. A hybrid carcinoma: adenoid cystic carcinoma and salivary duct carcinoma of the salivary gland. An immunohistochemical study. Virchows Arch. 1997;430(6):495–500. doi: 10.1007/s004280050060. - DOI - PubMed

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