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Review
. 2014 Oct;31(10):1474-87.
doi: 10.1039/c4np00073k.

Biosynthesis of fungal indole alkaloids

Wei Xu  1 , Diego J Gavia, Yi Tang
Affiliations
Review

Biosynthesis of fungal indole alkaloids

Wei Xu et al. Nat Prod Rep. 2014 Oct.

Abstract

This review provides a summary of recent research advances in elucidating the biosynthesis of fungal indole alkaloids. The different strategies used to incorporate and derivatize the indole/indoline moieties in various families of fungal indole alkaloids will be discussed, including tryptophan-containing nonribosomal peptides, polyketide-nonribosomal peptide hybrids, and alkaloids derived from other indole building blocks. This review also includes a discussion regarding the downstream modifications that generate chemical and structural diversity among indole alkaloids.

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Figures

Figure 1
Figure 1
A sequence logo representation of the 10 AA code for NRPS A-domains specificity. A) A domains that are specific for 1. B) All the fungal A domains in NRPSpredictor2 database. The residue numbering is based on PheA.
Scheme 1
Scheme 1
Origins of Indole Moieties in Fungal Indole Alkaloids
Scheme 2
Scheme 2
Common Reactions on Indole Ring.
Scheme 3
Scheme 3
Biosynthesis of Dipeptide Indole Alkaloids.
Scheme 4
Scheme 4
Biosynthesis of Tripeptide Indole Alkaloids
Scheme 5
Scheme 5
Biosynthesis of PKS-NRPS Derived Indole Alkaloids
Scheme 6
Scheme 6
Biosynthesis of Fungal Indole diterpenes.
Scheme 7
Scheme 7
Biosynthesis of Indole Alkaloids from Other Indole Precursors
See this image and copyright information in PMC

References

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