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Review
. 2015 Jan 20;112(2):217-26.
doi: 10.1038/bjc.2014.476. Epub 2014 Sep 2.

Beyond BRAF: where next for melanoma therapy?

I V Fedorenko  1 , G T Gibney  2 , V K Sondak  2 , K S M Smalley  3
Affiliations
Review

Beyond BRAF: where next for melanoma therapy?

I V Fedorenko et al. Br J Cancer. .

Abstract

In recent years, melanoma has become a poster-child for the development of oncogene-directed targeted therapies. This approach, which has been exemplified by the development of small-molecule BRAF inhibitors and the BRAF/MEK inhibitor combination for BRAF-mutant melanoma, has brought new hope to patients. Despite these successes, treatment failure seems near inevitable in the majority of cases—even in individuals treated with the BRAF/MEK inhibitor doublet. In the current review, we discuss the future of combination strategies for patients with BRAF-mutant melanoma as well as the emerging therapeutic options for patients with NRAS-mutant and BRAF/NRAS-wild-type melanoma. We also outline some of the newest developments in the in-depth personalisation of therapy that should allow melanoma treatment to continue shaping the field precision cancer medicine.

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