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. 2014 Oct 28;111(9):1824-30.
doi: 10.1038/bjc.2014.479. Epub 2014 Sep 2.

Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland

K G J Pollock  1 , K Kavanagh  2 , A Potts  1 , J Love  1 , K Cuschieri  3 , H Cubie  3 , C Robertson  1 , M Cruickshank  4 , T J Palmer  5 , S Nicoll  6 , M Donaghy  1
Affiliations

Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland

K G J Pollock et al. Br J Cancer. .

Abstract

Background: In Scotland, a national HPV immunisation programme began in 2008 for 12- to 13-year olds, with a catch-up campaign from 2008 to 2011 for those under the age of 18. To monitor the impact of HPV immunisation on cervical disease at the population level, a programme of national surveillance was established.

Methods: We analysed colposcopy data from a cohort of women born between 1988 and 1992 who entered the Scottish Cervical Screening Programme (SCSP) and were aged 20-21 in 2008-2012.

Results: By linking datasets from the SCSP and colposcopy services, we observed a significant reduction in diagnoses of cervical intraepithelial neoplasia 1 (CIN 1; RR 0.71, 95% CI 0.58 to 0.87; P=0.0008), CIN 2 (RR 0.5, 95% CI 0.4 to 0.63; P<0.0001) and CIN 3 (RR 0.45, 95% CI 0.35 to 0.58; P<0.0001) for women who received three doses of vaccine compared with unvaccinated women.

Conclusions: To our knowledge, this is one of the first studies to show a reduction of low- and high-grade CIN associated with high uptake of the HPV bivalent vaccine at the population level. These data are very encouraging for countries that have achieved high HPV vaccine uptake.

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Figures

Figure 1
Figure 1
Incidence rates per 1000 person-year (p1000py) and associated 95% confidence intervals of CIN 1, 2 and 3 stratified by birth cohort and vaccination status (unvaccinated vs fully vaccinated with three doses).
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References

    1. Baker D, Middleton E. Cervical screening and health inequality in England in the 1990s. J Epidemiol Community Health. 2003;57:417–423. - PMC - PubMed
    1. Baldur-Felskov B, Dehlendorff C, Munk C, Kjaer SK. Early impact of human papillomavirus vaccination on cervical neoplasia—nationwide follow-up of young Danish women. J Natl Cancer Inst. 2014;106:djt460. - PubMed
    1. Bhopal RS, Bansal N, Steiner M, Brewster DH, Scottish Health and Ethnicity Linkage Study Does the ‘Scottish effect' apply to all ethnic groups? All-cancer, lung, colorectal, breast and prostate cancer in the Scottish Health and Ethnicity Linkage Cohort Study. BMJ Open. 2012;2:pii: e001957. - PMC - PubMed
    1. Bowyer HL, Marlow LA, Hibbitts S, Pollock KG, Waller J. Knowledge and awareness of HPV and the HPV vaccine among young women in the first routinely vaccinated cohort in England. Vaccine. 2013;31:1051–1056. - PubMed
    1. Brotherton JML, Fridman M, May CL, Chappell G, Saville AM, Gertig DM. Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological study. Lancet. 2011;377:2085–2092. - PubMed

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