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. 2014 Apr;4(4):290-3.
doi: 10.12980/APJTB.4.2014B878.

In vitro antioxidant and cytotoxic activities of essential oil of Feronia elephantum Correa

Ramaraj Thirugnanasampandan  1 , Delma David  1
Affiliations

In vitro antioxidant and cytotoxic activities of essential oil of Feronia elephantum Correa

Ramaraj Thirugnanasampandan et al. Asian Pac J Trop Biomed. 2014 Apr.

Abstract

Objective: To analyse the chemical composition and evaluation of antioxidant, cytotoxic and DNA fragmentation activities of essential oil of Feronia elephantum Correa.

Methods: Chemical composition analysis of hydrodistilled essential oil was determined by gas chromatography-mass spectrometry and in vitro antioxidant activity of oil was determined by DPPH free radical, hydroxyly radical scavenging, metal chelating and prevention of deoxyribose degradation. Cytotoxicity and DNA fragmentation activities against breast cancer cells (MCF-7) were also analyzed.

Results: Gas chromatography-mass spectrometry analysis revealed the presence of 24 compounds with caryophyllene oxide (62.29%) as major compound. A considerable antioxidant, cyotoxic and DNA fragmentation activities of oils was observed.

Conclusions: The result of this study clearly indicates oil could be useful for food preservation and preparation.

Keywords: Antioxidant; Cytotoxicity; DNA fragmentation; Essential oil; Feronia elephantum.

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Conflict of interest statement

Conflict of interest statement: We declare that we have no conflict of interest.

Figures

Figure 1.
Figure 1.. DNA fragmentation of MCF-7 cells treated with essential oil of F. elephantum.
Lane 1: Marker 1 000 bp ladder; Lane 2: Control; Lane 3: Con: 312 µg/mL; Lane 4: Con: 625 µg/mL; Lane 5: Con: 1 250 µg/mL.
See this image and copyright information in PMC

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