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. 2014 Nov;58(11):6978-81.
doi: 10.1128/AAC.03648-14. Epub 2014 Sep 2.

Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R

Ester Pietta  1 , Maria Camila Montealegre  2 , Jung Hyeob Roh  3 , Pier Sandro Cocconcelli  4 , Barbara E Murray  5
Affiliations

Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R

Ester Pietta et al. Antimicrob Agents Chemother. 2014 Nov.

Abstract

During a study to investigate the evolution of ampicillin resistance in Enterococcus faecium, we observed that a number of E. faecium strains, mainly from the recently described subclade A2, showed PBP5 sequences in between PBP5-S and PBP5-R. These hybrid PBP5-S/R patterns reveal a progression of amino acid changes from the S form to the R form of this protein; however, these changes do not strictly correlate with changes in ampicillin MICs.

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References

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