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Review
. 2014 May;4(Suppl 1):S1-7.
doi: 10.12980/APJTB.4.2014C980.

Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine

Thirumurugan Gunasekaran  1 , Tedesse Haile  1 , Tedele Nigusse  1 , Magharla Dasaratha Dhanaraju  2
Affiliations
Review

Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine

Thirumurugan Gunasekaran et al. Asian Pac J Trop Biomed. 2014 May.

Abstract

To achieve the desired therapeutic objective, the drug product must deliver the active drug at an optimal rate and amount. By proper biopharmaceutic design, the rate and extent of drug absorption (also called as bioavailability) or the systemic delivery of drugs to the body can be varied from rapid and complete absorption to slow and sustained absorption depending upon the desired therapeutic objective. Phytomedicine have served as the foundation for a larger fraction of the current pharmacopeia. But the delivery of phytomedicine is always problematic due to poor aqueous solubility, poor permeation, low systemic availability, instability and extensive first pass metabolism. Current review will discuss in detail about how nanotechnology can enhance the bioavilability and bioactivity of the phytomedicine.

Keywords: Bioactivity; Bioavailability; Nanotechnology; Phytomedicine.

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Conflict of interest statement

Conflict of interest statement: We declare that we have no conflict of interest.

Figures

Figure 1.
Figure 1.. Applications of nanotechnology based phytomedicine formulation.
Figure 2.
Figure 2.. The two rate-determining steps in the absorption of orally administered phytomedicine formulation.
Figure 3.
Figure 3.. Use of surface modification in phytomedicine drug delivery.
Figure 4.
Figure 4.. Release of phytomedicine from the polymer scaffold.
Figure 5.
Figure 5.. Common techniques used in nanophytomedicine formulation.
Figure 6.
Figure 6.. Various types of nanophytopharmaceuticals.
Figure 7.
Figure 7.. Nanophytomedicine enhances the bioavailability and bioactivity of phytomedicine.
See this image and copyright information in PMC

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