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. 2014 May;4(Suppl 1):S436-41.
doi: 10.12980/APJTB.4.2014C1252.

Broad spectrum anthelmintic potential of Cassia plants

Suman Kundu  1 , Saptarshi Roy  1 , Larisha Mawkhleing Lyndem  1
Affiliations

Broad spectrum anthelmintic potential of Cassia plants

Suman Kundu et al. Asian Pac J Trop Biomed. 2014 May.

Abstract

Objective: To study the in vitro anthelmintic efficacy of Cassia alata (C. alata), Cassia angustifolia (C. angustifolia) and Cassia occidentalis (C. occidentalis).

Methods: Crude ethanol extract from leaves of the three plants were prepared in rotary evaporator and different concentrations (10, 20 and 40 mg/mL) of leaf extracts were used for treatment on different representatives of helminthes (Heterakis gallinarum, Raillietina tetragona and Catatropis sp.) from domestic fowl (Gallus gallus domesticus). Loss of motility and death were monitored frequently.

Results: C. alata showed early paralysis in all worms treated followed by C. angustifolia. C. occidentalis in combination with C. alata together caused early paralysis in all treated worms than the combination of C. alata with C. angustfolia. While Heterakis gallinarum in control survived for (81.33±2.07) h, treated worms lost their motility at (5.71±0.10) h, (6.60±0.86) h and (13.95±0.43) h with C. angustifolia, C. alata and C. occidentalis respectively at a concentration of 40 mg/mL which showed better efficacy than albendazole. Catatropis sp. survival period was (26.49±1.38) h in control, but with plant treatment, it lost its motility in just (0.57±0.08) h, (1.00±0.12) h and (1.47±0.40) h at 40 mg/mL concentration of C. alata, C. angustifolia and C. occidentalis respectively. Raillietina tetragona on the other hand became paralysed at (1.68±0.27) h, (2.95±0.29) h and (4.13±0.31) h with above concentrations treated with three plants respectively, however in control it survived up to (81.93±4.71) h.

Conclusions: This present study indicated broad spectrum vermifugal activity of all plants tested.

Keywords: Anthelmintic; Cassia; Extracts; Paralysis; Parasites; Vermifugal.

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Conflict of interest statement

Conflict of interest statement: We declare that we have no conflict of interest.

Figures

Figure 1.
Figure 1.. Effect of combinations of Cassia plant extracts on H. galinarum.
Cal: C. alata; Cag: C. angustifolia; Coc: C. occidentalis.
Figure 2.
Figure 2.. Effect of combinations of Cassia plant extracts on R. tetragona.
Cal: C. alata; Cag: C. angustifolia; Coc: C. occidentalis.
Figure 3.
Figure 3.. Effect of combinations of Cassia plant extracts on Catatropis sp.
Cal: C. alata; Cag: C. angustifolia; Coc: C. occidentalis.
See this image and copyright information in PMC

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