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. 2014 Jul-Aug;80(4):290-5.
doi: 10.1016/j.bjorl.2014.05.016. Epub 2014 Jun 11.

Histologic correlation of expression of Ki-67 in squamous cell carcinoma of the glottis according to the degree of cell differentiation

Rodrigo Gonzalez Bonhin  1 , Guilherme Machado de Carvalho  2 , Alexandre Caixeta Guimarães  2 , Carlos Takahiro Chone  2 , Agrício Nubiato Crespo  2 , Albina Messias de Almeida Milani Altemani  3 , Eliane M I Amstalden  3
Affiliations

Histologic correlation of expression of Ki-67 in squamous cell carcinoma of the glottis according to the degree of cell differentiation

Rodrigo Gonzalez Bonhin et al. Braz J Otorhinolaryngol. 2014 Jul-Aug.

Abstract
in English, Portuguese

Introduction: Squamous cell carcinoma is the most common neoplasm of the larynx and glottis, and its prognosis depends on the size of the lesion, level of local invasion, cervical lymphatic spread, and presence of distant metastases. Ki-67 (MKI67) is a protein present in the core, whose function is related to cell proliferation.

Aim: To evaluate the expression of marker Ki-67 in squamous cell carcinoma of the larynx and glottis and its correlation to pathological findings.

Methods: Experimental study with immunohistochemistry analysis of Ki-67, calculating the percentage of the cell proliferation index in glottic squamous cell carcinomas.

Results: Sixteen cases were analyzed, with six well-differentiated and 10 poorly/moderately differentiated tumors. There was a correlation between cell proliferation index and degree of cell differentiation, with higher proliferation in poorly/moderately differentiated tumors.

Conclusion: The cell proliferation index, as measured by Ki-67, may be useful in the characterization of histological degree in glottic squamous cell tumors.

Introdução: O carcinoma de células escamosas é a neoplasia mais frequente da laringe e da região glótica, seu prognóstico depende do tamanho da lesão, do nível de invasão local, disseminação cervical linfática e da existência de metástases à distância. Ki-67 (MKI67) é uma proteína presente no núcleo, cuja função está relacionada com a proliferação celular.

Objetivos: Avaliar a expressão do marcador Ki-67 em carcinoma de células escamosas da laringe glóticos e correlacionar sua expressão com os achados anatomopatológicos.

Método: Trabalho experimental de análise imunohistoquímica do Ki 67 através do cálculo percentual do índice de proliferação celular em produtos de carcinomas epidermóides glóticos.

Resultados: Dezesseis casos foram analisados, sendo seis bem diferenciados e dez pouco/moderadamente diferenciados. Houve correlação entre o índice de proliferação celular e o grau de diferenciação celular, sendo a proliferação maior nos pouco/moderadamente diferenciados.

Conclusão: O índice de proliferação celular, medido pelo Ki-67 pode ser útil na caracterização do grau histológico em tumores glóticos de células escamosas.

Keywords: Biological markers; Carcinoma de células escamosas; Carcinoma, squamous cell; Cell proliferation; Glote; Glottis; Head and neck neoplasms; Marcadores biológicos; Neoplasias de cabeça e pescoço; Proliferação de células.

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Figures

Figure 1
Figure 1
Phases of cell cycle. G1, S, G – presence of MKI67.
See this image and copyright information in PMC

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