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Comment
. 2014 Aug 27;18(4):461.
doi: 10.1186/s13054-014-0461-9.

There's life in the old dog yet: vitamin C as a therapeutic option in endothelial dysfunction

Sandra Rodemeister  1 , Hans K Biesalski  2
Affiliations
Comment

There's life in the old dog yet: vitamin C as a therapeutic option in endothelial dysfunction

Sandra Rodemeister et al. Crit Care. .

Abstract

The use of vitamin C against different diseases has been controversially and emotionally discussed since Linus Pauling published his cancer studies. In vitro and animal studies showed promising results and explained the impact of vitamin C, particularly in cases with endothelial dysfunction. Indeed, studies (reviewed in this issue of Critical Care by Oudemans-van Straaten and colleagues) using high-dose vitamin C and the parenteral route of application seem to be more successful than oral vitamin C delivery.

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Comment on

  • Vitamin C revisited.
    Oudemans-van Straaten HM, Spoelstra-de Man AM, de Waard MC. Oudemans-van Straaten HM, et al. Crit Care. 2014 Aug 6;18(4):460. doi: 10.1186/s13054-014-0460-x. Crit Care. 2014. PMID: 25185110 Free PMC article. Review.

References

    1. Biesalski HK, McGregor GP. Antioxidant therapy in critical care – is the microcirculation the primary target? Crit Care Med. 2007;35(9 Suppl):S577–S583. doi: 10.1097/01.CCM.0000278598.95294.C5. - DOI - PubMed
    1. Oudemans-van Straaten HM, Spoelstra-de Man AM, de Waard MC. Vitamin C revisited. Crit Care. 2014;18:460. doi: 10.1186/s13054-014-0460-x. - DOI - PMC - PubMed
    1. Sena CM, Pereira AM, Seica R. Endothelial dysfunction – a major mediator of diabetic vascular disease. Biochim Biophys Acta. 2013;1832:2216–2231. doi: 10.1016/j.bbadis.2013.08.006. - DOI - PubMed
    1. Kietadisorn R, Juni RP, Moens AL. Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities. Am J Physiol Endocrinol Metab. 2012;302:E481–E495. doi: 10.1152/ajpendo.00540.2011. - DOI - PubMed
    1. Schmidt TS, Alp NJ. Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease. Clin Sci (Lond) 2007;113:47–63. - PubMed