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Comment
. 2014 Sep;4(9):995-7.
doi: 10.1158/2159-8290.CD-14-0743.

Tracing the roots of cancer evolution

Yanwen Jiang  1 , Olivier Elemento  2
Affiliations
Comment

Tracing the roots of cancer evolution

Yanwen Jiang et al. Cancer Discov. 2014 Sep.

Abstract

By comparing the genomes of progenitor cells and mature cells of lymphoid and myeloid lineages in patients with chronic lymphocytic leukemia (CLL), Damm and colleagues confirmed that CLL originates from preleukemic CD34(+) progenitor cells and identified early CLL mutations that are associated with these progenitor cells. Moreover, they discovered that deregulation of B-cell receptor signaling may be one of the hallmarks of CLL, particularly in tumors with EGR2 mutations.

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest

The authors disclose no potential conflicts of interest.

Comment on

  • Acquired initiating mutations in early hematopoietic cells of CLL patients.
    Damm F, Mylonas E, Cosson A, Yoshida K, Della Valle V, Mouly E, Diop M, Scourzic L, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Kikushige Y, Davi F, Lambert J, Gautheret D, Merle-Béral H, Sutton L, Dessen P, Solary E, Akashi K, Vainchenker W, Mercher T, Droin N, Ogawa S, Nguyen-Khac F, Bernard OA. Damm F, et al. Cancer Discov. 2014 Sep;4(9):1088-101. doi: 10.1158/2159-8290.CD-14-0104. Epub 2014 Jun 11. Cancer Discov. 2014. PMID: 24920063

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