Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Sep;4(9):OF9.
doi: 10.1158/2159-8290.CD-RW2014-151. Epub 2014 Jul 17.

HNF-4α-mediated hepatocyte differentiation is blocked by mutant IDH

No authors listed
Comment

HNF-4α-mediated hepatocyte differentiation is blocked by mutant IDH

No authors listed. Cancer Discov. 2014 Sep.

Abstract

Mutant IDH prevents hepatocyte differentiation and promotes tumorigenesis via HNF-4α inhibition.

PubMed Disclaimer

Comment on

  • Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
    Saha SK, Parachoniak CA, Ghanta KS, Fitamant J, Ross KN, Najem MS, Gurumurthy S, Akbay EA, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J, Popovici-Muller J, Gliser C, Ferrone CR, Apte U, Llovet JM, Wong KK, Ramaswamy S, Bardeesy N. Saha SK, et al. Nature. 2014 Sep 4;513(7516):110-4. doi: 10.1038/nature13441. Epub 2014 Jul 2. Nature. 2014. PMID: 25043045 Free PMC article.

LinkOut - more resources