Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Sep 2;20(3):408-15.
doi: 10.1016/j.cmet.2014.07.025.

Brown fat in humans: consensus points and experimental guidelines

Aaron M Cypess  1 , Carol R Haft  2 , Maren R Laughlin  3 , Houchun H Hu  4
Affiliations

Brown fat in humans: consensus points and experimental guidelines

Aaron M Cypess et al. Cell Metab. .

Abstract

As part of a current worldwide effort to understand the physiology of human BAT (hBAT) and whether its thermogenic activity can be manipulated to treat obesity, the workshop "Exploring the Roles of Brown Fat in Humans" was convened at the National Institutes of Health on February 25-26, 2014. Presentations and discussion indicated that hBAT and its physiological roles are highly complex, and research is needed to understand the health impact of hBAT beyond thermogenesis and body weight regulation, and to define its interactions with core physiological processes like glucose homeostasis, cachexia, physical activity, bone structure, sleep, and circadian rhythms.

PubMed Disclaimer

References

    1. Arunachalam K, Stauffer PR, Maccarini PF, Jacobsen S, Sterzer F. Characterization of a digital microwave radiometry system for noninvasive thermometry using a temperature-controlled homogeneous test load. Phys Med Biol. 2008;53:3883–3901. - PMC - PubMed
    1. Azhdarinia A, Daquinag AC, Tseng C, Ghosh SC, Ghosh P, Amaya-Manzanares F, Sevick-Muraca E, Kolonin MG. A peptide probe for targeted brown adipose tissue imaging. Nat. Commun. 2013;4:2472. doi: 10.1038/ncomms3472. - PMC - PubMed
    1. Baba S, Jacene HA, Engles JM, Honda H, Wahl RLCT. Hounsfield units of brown adipose tissue increase with activation: preclinical and clinical studies. J Nucl Med. 2010;51:246–250. - PubMed
    1. Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, Lowell BB. BetaAR signaling required for diet-induced thermogenesis and obesity resistance. Science. 2002;297:843–845. - PubMed
    1. Bauwens M, Wierts R, van Royen B, Bucerius J, Backes W, Mottaghy F, Brans B. Molecular imaging of brown adipose tissue in health and disease. Eur. J. Nucl. Med. Mol. Imaging. 2014;41:776–791. - PubMed

Publication types

Substances