Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Nov;112(5):868-75.
doi: 10.1160/TH14-04-0311. Epub 2014 Sep 4.

In vivo activation and functions of the protease factor XII

Jenny Björkqvist, Katrin F Nickel, Evi Stavrou, Thomas Renné  1
Affiliations
Review

In vivo activation and functions of the protease factor XII

Jenny Björkqvist et al. Thromb Haemost. 2014 Nov.

Abstract

Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. The biochemistry of the contact system in vitro is well understood; however, its in vivo functions are just beginning to emerge. The current review concentrates on activators and functions of the FXII-driven contact system in vivo. Elucidating its physiologic activities offers the exciting opportunity to develop strategies for the safe interference with both thrombotic and inflammatory diseases.

Keywords: Coagulation factors; contact phase; proteases.

PubMed Disclaimer

Publication types

MeSH terms