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. 2014 Sep 17;136(37):12836-9.
doi: 10.1021/ja507034d. Epub 2014 Sep 4.

A mononuclear manganese(II) complex demonstrates a strategy to simultaneously image and treat oxidative stress

Meng Yu  1 , Stephen L Ambrose, Zachary L Whaley, Sanjun Fan, John D Gorden, Ronald J Beyers, Dean D Schwartz, Christian R Goldsmith
Affiliations

A mononuclear manganese(II) complex demonstrates a strategy to simultaneously image and treat oxidative stress

Meng Yu et al. J Am Chem Soc. .

Erratum in

Abstract

A manganese(II) complex with a ligand containing an oxidizable quinol group serves as a turn-on sensor for H2O2. Upon oxidation, the relaxivity of the complex in buffered water increases by 0.8 mM(-1) s(-1), providing a signal that can be detected and quantified by magnetic resonance imaging. The complex also serves as a potent antioxidant, suggesting that this and related complexes have the potential to concurrently visualize and alleviate oxidative stress.

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