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Comment
. 2014 Sep 23;111(38):13684-5.
doi: 10.1073/pnas.1414572111. Epub 2014 Sep 3.

A previously undescribed tubulin binder

Jessica J Field  1 , Andrew B Waight  1 , Peter D Senter  2
Affiliations
Comment

A previously undescribed tubulin binder

Jessica J Field et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Structural overview of MT-binding sites on tubulin heterodimers. (A) Two αβ heterodimers are displayed in the conformation seen in bovine brain tubulin crystal structures (5). The α and β subunits are colored in slate and gray, respectively. Representative MT-binding compounds are depicted as space-filling models, shown in their approximate binding positions. (B) Detail of the vinca site structural features. The bound GDP molecule is shown in stick representation for reference. The approximate location of the maytansine site described by Prota et al. (5) is located below the bound GDP.
See this image and copyright information in PMC

Comment on

References

    1. Desai A, Mitchison TJ. Microtubule polymerization dynamics. Annu Rev Cell Dev Biol. 1997;13:83–117. - PubMed
    1. Dumontet C, Jordan MA. Microtubule-binding agents: A dynamic field of cancer therapeutics. Nat Rev Drug Discov. 2010;9(10):790–803. - PMC - PubMed
    1. Ben-Chetrit E, Bergmann S, Sood R. Mechanism of the anti-inflammatory effect of colchicine in rheumatic diseases: A possible new outlook through microarray analysis. Rheumatology. 2006;45:274–282. - PubMed
    1. Ballatore C, et al. Microtubule stabilizing agents as potential treatment for Alzheimer’s disease and related neurodegenerative tauopathies. J Med Chem. 2012;55(21):8979–8996. - PMC - PubMed
    1. Prota AE, et al. A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc Natl Acad Sci USA. 2014;111:13817–13821. - PMC - PubMed

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