AP1, a composite transcription factor implicated in abnormal growth control

Abstract

Growth factors activate cascades of intracellular events, some of which result in altered gene expression. A series of recent discoveries have highlighted the role of the transcription factor AP1 as a mediator of the effects of growth factors, as well as those of oncogenes and the tumour promoter TPA. We discuss the molecular composition of AP1, how its activity is thought to be regulated, and the evidence that AP1 activation is involved in transformation.