Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Sep;33(9):445-57.
doi: 10.5732/cjc.014.10123.

Cancer immunotherapy in clinical practice -- the past, present, and future

Gaurav Goel  1 , Weijing Sun
Affiliations

Cancer immunotherapy in clinical practice -- the past, present, and future

Gaurav Goel et al. Chin J Cancer. 2014 Sep.

Abstract

Considerable progress has been made in the field of cancer immunotherapy in recent years. This has been made possible in large part by the identification of new immune-based cellular targets and the development of novel approaches aimed at stimulating the immune system. The role played by the immunosuppressive microenvironment in the development of tumors has been established. The success of checkpoint-inhibiting antibodies and cancer vaccines has marked the beginning of a new era in cancer treatment. This review highlights the clinically relevant principles of cancer immunology and various immunotherapeutic approaches that have either already entered mainstream oncologic practice or are currently in the process of being evaluated in clinical trials. Furthermore, the current barriers to the development of effective immunotherapies and the potential strategies of overcoming them are also discussed.

PubMed Disclaimer

References

    1. Coley WB., II Contribution to the knowledge of sarcoma. Ann Surg. 1891;14:199–220. - PMC - PubMed
    1. Clauberg KW. The immunobiological legacy of Emil von Behring and Paul Ehrlich. Dtsch Med J. 1954;5:138–146. [in undetermined language] - PubMed
    1. Burnet M. Cancer; a biological approach. I. The processes of control. Br Med J. 1957;1:779–786. - PMC - PubMed
    1. Thomas L, Lawrence HS. Cellular and humoral aspects of the hypersensitive states. New York: Hoeber-Harper; 1959. pp. 529–532.
    1. Knuth A, Wolfel T, Klehmann E, et al. Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection. Proc Natl Acad Sci U S A. 1989;86:2804–2808. - PMC - PubMed