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Comment
. 2014 Oct 16;33(20):2281-2.
doi: 10.15252/embj.201489778. Epub 2014 Sep 4.

Deep diving in the blood stem cell-ome

Demetrios Kalaitzidis  1 , David T Scadden  1
Affiliations
Comment

Deep diving in the blood stem cell-ome

Demetrios Kalaitzidis et al. EMBO J. .

Abstract

Defining the functional distinctions between cells comprising the bone marrow has yielded fundamental insights into lineage ordering and drivers of blood cell production. A novel, highly granular and multi-dimensional molecular characterization of functional subsets of hematopoietic stem- and progenitor cells recently published in Cell Stem Cell (Cabezas-Wallscheid et al, 2014) will serve as a landmark and treasure trove for unanticipated insights into basic biology and the development of future targeted medicine.

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Figures

Figure 1
Figure 1. Application of global profiling methods for the study of HSC biology
Cabezas-Wallscheid et al (2014) performed multiple unbiased profiling methods (listed) on an HSC-enriched populations (HSC-EP) and 4 other distinct hematopoietic progenitor populations (HPC). They identified multiple pathways upregulated in HSC-EP, as well as provided a rich resource of multiple data types for stem-cell biology.
See this image and copyright information in PMC

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References

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