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Editorial
. 2014 Sep 4;106(9):dju233.
doi: 10.1093/jnci/dju233. Print 2014 Sep.

Avoiding the bad and enhancing the good of soy supplements in breast cancer

V Craig Jordan  1
Affiliations
Editorial

Avoiding the bad and enhancing the good of soy supplements in breast cancer

V Craig Jordan. J Natl Cancer Inst. .
No abstract available

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Figures

Figure 1.
Figure 1.
Rules for the change in estrogen receptor (ER) positive breast cancer cell populations as they leave an estrogen rich environment at menopause, adapt to a declining estrogen environment over a 5 year period (referred to as Gap). Estrogen independent clones then grow out that are able to survive in an estrogen austere environment. This is modeled in the laboratory with long term estrogen deprived cells that exhibit acquired hypersensitivity to estrogen for growth(6) and then estrogen induced apoptosis(14,15). Laboratory studies illustrate that the constituents of conjugated equine estrogen (CEE)(26), the endocrine disruptor bisphenol A (27) and phytoestrogens(24) can trigger cell replication or apoptosis dependent upon the cell populations and its natural estrogen rich or austere environment.
See this image and copyright information in PMC

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References

    1. Shike M, Doane A, Russo L, et al. The effects of soy supplementation on gene expression in breast cancer: a randomized placebo-controlled study. J Natl Cancer Inst. 2014: In Press. - PMC - PubMed
    1. Jordan VC, Koch R, Lieberman ME. Structure-activity relationships of nonsteroidal estrogens and antiestrogens. In: Jordan VC, ed. Estrogen/Antiestrogen Action and Breast Cancer Therapy. Madison, WI: University of Wisconsin Press; 1986:19–41.
    1. Welshons WV, Jordan VC. Adaptation of estrogen-dependent MCF-7 cells to low estrogen (phenol red-free) culture. Eur J Cancer Clin Oncol. 1987;23(12):1935–9. - PubMed
    1. Katzenellenbogen BS, Kendra KL, Norman MJ, et al. Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens. Cancer Res. 1987;47(16):4355–4360. - PubMed
    1. Masamura S, Santner SJ, Heitjan DF, et al. Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells. J Clin Endocrinol Metab. 1995;80(10):2918–2925. - PubMed

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