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Comment
. 2014 Sep 4;124(10):1548-9.
doi: 10.1182/blood-2014-06-576975.

Taking a leaf from the book of oral tolerance

David W Scott  1
Affiliations
Comment

Taking a leaf from the book of oral tolerance

David W Scott. Blood. .

Abstract

In this issue of Blood, Sherman et al demonstrate that mucosal delivery of engineered tobacco leaves can lead to tolerance to factor VIII (FVIII) inhibitor production. Eat your veggies for tolerance!

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Proposed clinical application: FVIII domains expressed in transgenic plants can be ingested and processed by the mucosal immune system to induce tolerance to FVIII.
See this image and copyright information in PMC

Comment on

References

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    1. Weiner HL, da Cunha AP, Quintana F, Wu H. Oral tolerance. Immunol Rev. 2011;241(1):241–259. - PMC - PubMed