Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Apr;7(2):143-7.
doi: 10.4103/0974-1208.138874.

Effect of endometriosis on implantation rates when compared to tubal factor in fresh non donor in vitro fertilization cycles

Neeta Singh  1 , Kusum Lata  1 , Moumita Naha  1 , Neena Malhotra  1 , Abhinash Tiwari  1 , Perumal Vanamail  1
Affiliations

Effect of endometriosis on implantation rates when compared to tubal factor in fresh non donor in vitro fertilization cycles

Neeta Singh et al. J Hum Reprod Sci. 2014 Apr.

Abstract

Objective: The objective of the following study is to compare the outcome of in vitro fertilization and embryo transfer (IVF-ET) in women with endometriosis and tubal-factor infertility.

Design: Retrospective study.

Setting: Tertiary referral hospital, assisted reproductive technologies unit.

Materials and method: The study group consisted of 78 women diagnosed with advanced stage endometriosis. The control group included 100 women with tubal-factor infertility. These groups were retrospectively analyzed regarding stimulation, fertilization, embryo development, implantation and pregnancy outcome.

Intervention s: Controlled ovarian hyperstimulation and IVF-ET.

Results: Lower oocyte yield with lower fertilization rate were found in women with endometriosis compared with tubal-factor control subjects. However, no differences were found in cleavage, implantation and clinical pregnancy rates between the endometriosis and tubal-factor groups.

Conclusions: Our results showed that women with endometriosis have a lower oocyte yield and lower fertilization rate compared with women with tubal-factor infertility. However, once the oocyte is fertilized, it seems that the embryo has a normal chance of implantation, leading to similar pregnancy rates and adequately treated women with endometriosis have equal chances of conception as seen with tubal-factor infertility.

Keywords: Endometriosis; implantation; in vitro fertilization-embryo transfer; infertility; ovarian reserve; pregnancy.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Kennedy S, Bergqvist A, Chapron C, D’Hooghe T, Dunselman G, Greb R, et al. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. 2005;20:2698–704. - PubMed
    1. Verkauf BS. Incidence, symptoms, and signs of endometriosis in fertile and infertile women. J Fla Med Assoc. 1987;74:671–5. - PubMed
    1. Kissler S, Hamscho N, Zangos S, Wiegratz I, Schlichter S, Menzel C, et al. Uterotubal transport disorder in adenomyosis and endometriosis: A cause for infertility. BJOG. 2006;113:902–8. - PubMed
    1. Mio Y, Toda T, Harada T, Terakawa N. Luteinized unruptured follicle in the early stages of endometriosis as a cause of unexplained infertility. Am J Obstet Gynecol. 1992;167:271–3. - PubMed
    1. Hull MG, Williams JA, Ray B, McLaughlin EA, Akande VA, Ford WC. The contribution of subtle oocyte or sperm dysfunction affecting fertilization in endometriosis-associated or unexplained infertility: A controlled comparison with tubal infertility and use of donor spermatozoa. Hum Reprod. 1998;13:1825–30. - PubMed

LinkOut - more resources