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. 2014 Jan;13(1):22-7.
doi: 10.4103/1450-1147.138570.

Preparation and evaluation of Lu-(177) phytate Complex for Radiosynovectomy

Hassan Yousefnia  1 , Amir Reza Jalilian  1 , Samaneh Zolghadri  1
Affiliations

Preparation and evaluation of Lu-(177) phytate Complex for Radiosynovectomy

Hassan Yousefnia et al. World J Nucl Med. 2014 Jan.

Retraction in

Abstract

Lu-(177) of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 10(13) n/cm/s. The product was converted into chloride form which was further used for labeling of Lu(-177) phytate complex successfully with high radiochemical purity (>99.9%, instant thin layer chromatography, MeOH: H2O: Acetic acid, 4:4:2, as mobile phase). The complex stability and viscosity were checked in the final solution up to 7 days. The prepared complex solution (100 μCi/100 μl) was injected intra-articularly to the male rat knee joint. Leakage of radioactivity from the injection site and its distribution in organs were investigated up to 7 days. Approximately, all injected dose has remained in injection site 7 days after injection. The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology.

Keywords: Biodistribution; lutetium-177; phytate; radiosynovectomy.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Chemical formula for phytate
Figure 2
Figure 2
Gamma-ray spectrum for Lu-177 chloride solution used in this study
Figure 3
Figure 3
Instant thin layer chromatography chromatograms of Lu-177Cl3 solution in diethylenetriamene pentaacetate solution (pH = 5) (left) and 10% ammonium acetate:methanol (1:1) solution (right) using Whatman no. 2
Figure 4
Figure 4
Instant thin layer chromatography chromatograms of Lu-177-LuCl3 (left) and Lu-177-phytate solution (right) on Whatman no. 1 paper using methanol:water:acetic acid (4:4:2) mixture
Figure 5
Figure 5
Percentage of injected dose per gram (ID/g %) of Lu-177Cl3 in wild-type rat tissues at 2, 4, 24 and 48 h post injection
Figure 6
Figure 6
Percentage of injected dose per gram (ID/g %) of Lu-177-phytate in wild-type rat tissues at 2 h, 24 h, 5 d and 7 d post intravenous injection
Figure 7
Figure 7
Distribution of [Lu-177]-phytate in wild-type male rats, 4, 24, 120 h and 168 h after intra-articular injection of 100 μCi of compound. % ID-percentage of injected dose. Each bar presents mean± standard deviation (n=3)
Figure 8
Figure 8
Distribution of [Lu-177]-phytate in wild-type male rats excluding injected knee data at 4, 24, 48, 120 h and 144 h after intra-articular injection of 10 μCi of compound. % ID-percentage of injected dose. Each bar presents mean± standard deviation (n=3)
Figure 9
Figure 9
Scintigraphic images of Lu-177-phytate in wild-type rat tissues 1 week post intravenous injection
Figure 10
Figure 10
Scintigraphic images of Lu-177-phytate in wild-type rat knee 1 and 7 days post intra-articular injection
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