Long-term follow-up of serum immunoglobulin levels in blinatumomab-treated patients with minimal residual disease-positive B-precursor acute lymphoblastic leukemia
- PMID: 25192414
- PMCID: PMC4183773
- DOI: 10.1038/bcj.2014.64
Long-term follow-up of serum immunoglobulin levels in blinatumomab-treated patients with minimal residual disease-positive B-precursor acute lymphoblastic leukemia
Figures

Similar articles
-
Blinatumomab activity in a patient with Down syndrome B-precursor acute lymphoblastic leukemia.Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26824. Epub 2017 Sep 17. Pediatr Blood Cancer. 2018. PMID: 28921818
-
Pediatric posttransplant relapsed/refractory B-precursor acute lymphoblastic leukemia shows durable remission by therapy with the T-cell engaging bispecific antibody blinatumomab.Haematologica. 2014 Jul;99(7):1212-9. doi: 10.3324/haematol.2013.100073. Epub 2014 Apr 11. Haematologica. 2014. PMID: 24727818 Free PMC article.
-
Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia.Blood. 2018 Apr 5;131(14):1522-1531. doi: 10.1182/blood-2017-08-798322. Epub 2018 Jan 22. Blood. 2018. PMID: 29358182 Free PMC article. Clinical Trial.
-
Concepts in immuno-oncology: tackling B cell malignancies with CD19-directed bispecific T cell engager therapies.Ann Hematol. 2020 Oct;99(10):2215-2229. doi: 10.1007/s00277-020-04221-0. Epub 2020 Aug 27. Ann Hematol. 2020. PMID: 32856140 Free PMC article. Review.
-
Clinical applications and safety evaluation of the new CD19 specific T-cell engager antibody construct blinatumomab.Expert Opin Drug Saf. 2017 Oct;16(10):1191-1202. doi: 10.1080/14740338.2017.1338270. Epub 2017 Aug 20. Expert Opin Drug Saf. 2017. PMID: 28825327 Review.
Cited by
-
Short-course blinatumomab for refractory/relapse precursor B acute lymphoblastic leukemia in children.Front Pediatr. 2023 Aug 4;11:1187607. doi: 10.3389/fped.2023.1187607. eCollection 2023. Front Pediatr. 2023. PMID: 37601130 Free PMC article.
-
Bispecific T-Cell Engagers (BiTEs) as Treatment of B-Cell Lymphoma.J Clin Oncol. 2016 Apr 1;34(10):1131-3. doi: 10.1200/JCO.2015.64.9970. Epub 2016 Feb 16. J Clin Oncol. 2016. PMID: 26884583 Free PMC article. No abstract available.
-
Management of adverse effects of new monoclonal antibody treatments in acute lymphoblastic leukemia.Drugs Context. 2020 Oct 14;9:2020-7-2. doi: 10.7573/dic.2020-7-2. eCollection 2020. Drugs Context. 2020. PMID: 33110433 Free PMC article. Review.
-
Risk of Infections Secondary to the Use of Targeted Therapies in Hematological Malignancies.Life (Basel). 2023 May 28;13(6):1272. doi: 10.3390/life13061272. Life (Basel). 2023. PMID: 37374055 Free PMC article. Review.
-
Blinatumomab use in pediatric B-ALL: where are we now?Blood Adv. 2025 Aug 12;9(15):3946-3954. doi: 10.1182/bloodadvances.2024014043. Blood Adv. 2025. PMID: 40489801 Free PMC article. Review.
References
-
- Bargou R, Leo E, Zugmaier G, Klinger M, Goebeler M, Knop S, et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science. 2008;321:974–977. - PubMed
-
- Topp MS, Gokbuget N, Zugmaier G, Degenhard E, Goebeler ME, Klinger M, et al. Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL. Blood. 2012;120:5185–5187. - PubMed
-
- Topp MS, Kufer P, Gokbuget N, Goebeler M, Klinger M, Neumann S, et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol. 2011;29:2493–2498. - PubMed
-
- Murphy K. Janeway's Immunobiology. Vol 1. New York City: Garland Science - Taylor & Francis; 2011.
-
- van Tilburg CM, Bierings MB, Berbers GA, Wolfs TF, Pieters R, Bloem AC, et al. Impact of treatment reduction for childhood acute lymphoblastic leukemia on serum immunoglobulins and antibodies against vaccine-preventable diseases. Pediatr Blood Cancer. 2012;58:701–707. - PubMed
Publication types
MeSH terms
Substances
Associated data
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical