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Comment
. 2014 Oct;49(10):1531-4.
doi: 10.1007/s00127-014-0961-6. Epub 2014 Sep 6.

The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research

James B Kirkbride  1
Affiliations
Comment

The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research

James B Kirkbride. Soc Psychiatry Psychiatr Epidemiol. 2014 Oct.

Abstract

In this commentary I review the recent paper by Iyegbe et al. on "The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research". I discuss how the paper advances our knowledge of polygenic risk scores for use, amongst others, in gene-environment interaction studies and the opportunities and challenges such approaches will bring to our understanding of the epidemiology of psychotic disorders, including schizophrenia.

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