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. 2014 Dec:12:150-4.
doi: 10.1016/j.ajp.2014.08.005. Epub 2014 Aug 23.

Role of ranitidine in negative symptoms of schizophrenia--an open label study

Varun S Mehta  1 , Daya Ram  2
Affiliations

Role of ranitidine in negative symptoms of schizophrenia--an open label study

Varun S Mehta et al. Asian J Psychiatr. 2014 Dec.

Abstract

In this open label study, 75 patients with a diagnosis of schizophrenia were randomized to three groups of 25 each, receiving 150mg/day ranitidine, 300mg/day ranitidine and receiving only olanzapine. They were rated on PANSS at baseline, 4 and 8 weeks. There was a significant reduction in the scores of negative scale in patients receiving 300mg/day ranitidine in comparison to patients not receiving ranitidine at the end of 4 weeks but was not seen again when assessed at the end of 8 weeks. Though effective in reducing the negative symptoms, the effect was not sustained due to the tolerance to the actions of ranitidine.

Keywords: H2 blockers; Histamine; Negative symptoms.

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