Traditional uses, phytochemistry and pharmacological properties of the genus Peucedanum: a review

Abstract

Ethnopharmacological relevance: The genus Peucedanum (Apiaceae) comprising more than 120 species is widely distributed in Europe, Asia and Africa. The ethnopharmacologial history of this genus indicated that some extracts of aerial and underground parts of several Peucedanum species have been used in folk medicine for treatment of various conditions, such as cough, cramps, pain, rheumatism, asthma and angina. This review focuses on ethnopharmacological uses of Peucedanum species, as well as the phytochemical, pharmacological and toxicological studies on this genus. Through this review, I intend to highlight the known and potential effects of the Peucedanum species or their isolated compounds and show which traditional medicine uses have been supported by pharmacological investigations.

Methods: Information on the Peucedanum species was collected from scientific journals, books, thesis and reports via a library and electronic search (using Google Scholar, Pubmed, Scopus, Web of Science and ScienceDirect). This review covers the available literature from 1970 to the end of September 2013.

Results: Although, there are about 120 species in this genus, so far many species have received no or little attention and most of pharmacological studies were performed on just about 20 species. Many phytochemical investigations on this genus confirmed that Peucedanum species are rich in essential oils and coumarins. The present review article shows that Peucedanum species have a wide spectrum of pharmacological activities and the most reported activities of Peucedanum plants come back to the presence of coumarins, flavonoids, phenolics and essential oils.

Conclusions: The present review confirms that some Peucedanum species have emerged as a good source of the traditional medicine for treatment of inflammation, microbial infections, cardiopulmonary diseases and provides new insights for further investigations on isolated compounds, especially on praeruptorins, to find novel therapeutics and aid drug discovery. However, for using Peucedanum species to prevent and treat various diseases, additional pharmacological studies to find the mechanism of action, safety and efficacy of them before starting clinical trials are required.

Keywords: (+)-Praeruptorin A or Praeruptorin C (CID: 5320691); (+)-Praeruptorin B or Praeruptorin D (CID: 25717254); (+)-trans-kellactone (CID 11436940); (−)-Praeruptorin A (CID: 38347601); Apiaceae; Bergapten (CID: 2355); Columbianadin (CID: 6436246); Coumarins; Imperatorin (CID: 10212); Isosamidin (CID: 442133); Osthole (CID: 10228); Osthrutin (CID: 5281420); Ostruthol (CID: 6441273); Peucedanin (CID: 8616); Peucedanum; Pharmacological effects; Phytochemicals; Praeruptorin A (CID: 38347607); Praeruptorin B (CID: 5319259); Praeruptorin E (CID: 6440581); Pteryxin (CID: 5281425); Traditional uses; Visamminol (CID: 5315249); Xanthotoxin (CID: 4114)..