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. 2014 Jun;19(6):525-30.

Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled study

Victoria Omranifard  1 , Elham Shirzadi  1 , Saeid Samandari  1 , Hamid Afshar  2 , Mohammad Reza Maracy  3
Affiliations

Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled study

Victoria Omranifard et al. J Res Med Sci. 2014 Jun.

Abstract

Background: Proper management of depression in elderly population would improve the outcome of the disease and reduce its related disability and mortality. Use of memantine with minimal side effects and drug interaction seems reasonable in the elderly but its antidepressant activity is controversial. The aim of the current research is to investigate the effects of add-on memantine during citalopram therapy in elderly patients with depression, in Isfahan.

Materials and methods: In this double-blind, placebo controlled trial study; elderly patients aged more than 60 years who were recently diagnosed with depression, were enrolled. The selected patients were randomlysplit into two groups, viz. intervention and placebo groups. The intervention was memantine (20 mg daily) or identical placebo plus citalopram for 8 weeks. The severity of depression and quality of life was evaluated using Geriatric Depression Scale (GDS-15), Hamilton Rating Scale for depression (HRSD) and World Health Organization Quality of Life WHOQOL-BREF respectively. The mentioned scores were evaluated at baseline, 4 weeks and 8 weeks, after initiating the trial in two studied groups and compared with each other.

Results: 28 and 29 patients were studied in the intervention and placebo groups, respectively. Score of GDS-15, HRSD and WHO-QOL-BREF scales at baseline, 4 weeks and 8 weeks, after initiating trial did not change significantly after use of memantine (P > 0.05). There was no significant difference in mean +/- SD of GDS-15, HRSD and WHO-QOL-BREF scales among intervention and placebo groups (P > 0.05).

Conclusion: The outcome of this clinical trial did not support the antidepressant effect of add-on memantine in elderly patients with depression receiving citalopram. It is recommended to design further studies considering the limitations of the current study mentioned herein and the effect of memantine with other anti-depressant agents.

Keywords: Depression; geriatric; memantine; quality of life.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Consort diagram of the study
See this image and copyright information in PMC

References

    1. Michaud CM, Murray CJ, Bloom BR. Burden of disease — implications for future research. JAMA. 2001;285:535–9. - PubMed
    1. Murthy RS, editor. The World Health Report 2001. Mental Health: New Understanding, New Hope. Geneva, Switzerland: WHO; 2001. Burden of mental and behavioral disorders. 24Y29.
    1. Rangaswamy SM. Geneva: Switzerland: World Health Report: Mental Health: New understanding New Hope; 2001. The World Health Organization.
    1. Stordal E, Bjartveit Kruger M, Dahl NH, Kruger Q, Mykletun A, DahI AA. Depression in relation to age and gender in the general population: The Nord-Trondelag Health Study (HUNT) Acta Psychiatr Scand. 2001;104:210–6. - PubMed
    1. Namadian M, Ghobadi S, editors. Tehran: Ashena press; 2006. Evaluation of mental status old age s Zanjan on 2001. Persian. persian.

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