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. 2014:2014:890385.
doi: 10.1155/2014/890385. Epub 2014 Aug 14.

Early glottic cancer: role of MRI in the preoperative staging

Eugenia Allegra  1 , Pierpaolo Ferrise  1 , Serena Trapasso  1 , Orazio Trapuzzano  2 , Antonio Barca  2 , Stefania Tamburrini  3 , Aldo Garozzo  1
Affiliations

Early glottic cancer: role of MRI in the preoperative staging

Eugenia Allegra et al. Biomed Res Int. 2014.

Abstract

Introduction: Clinical staging is the most important time in management of glottic cancer in early stage (I-II). We have conducted a prospective study to evaluate if magnetic resonance imaging (MRI) is more accurate than computed tomography (CT) about tumoral extension, to exactly choose the most appropriate surgical approach, from organ preservation surgery to demolitive surgery. MATERIALS and

Methods: This prospective study was conducted on 26 male patients, with suspected laryngeal neoplasia of glottic region. The images of MRI and CT were analyzed to define the expansion of glottic lesion to anterior commissure, laryngeal cartilages, subglottic and/or supraglottic site, and paraglottic space. The results of MRI and CT were compared with each other and with the pathology report.

Results: CT accuracy was 70% with low sensitivity but with high specific value. MRI showed a diagnostic accuracy in 80% of cases, with a sensitivity of 100% and high specificity. Statistical analysis showed that MRI has higher correlation than CT with the pathology report.

Conclusion: Our study showed that MRI is more sensitive than CT in the preoperative staging of early glottic cancer, to select exactly the eligible patients in conservative surgery of the larynx, as supracricoid laryngectomy and cordectomy by CO2 laser.

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Figures

Figure 1
Figure 1
Carcinoma of the right vocal cord: (a) endoscopic view; (b) CT image: the paraglottic space seems preserved (green indicator) without cartilaginous alterations; (c) T2w MR image: the paraglottic space seems involved with focal invasion of the thyroid cartilage (green indicator).
Figure 2
Figure 2
Bilateral glottic carcinoma with involvement of anterior commissure: (a) endoscopic view; (b) CT image: contrast enhancement of right vocal fold, but the commissure seems preserved (green indicator); (c) T1w MR image after contrast shows involvement of right true vocal cord, anterior commissure, and anterior part of left vocal fold (green indicator).
See this image and copyright information in PMC

References

    1. Ortholan C, Benezery K, Dassonville O, et al. A specific approach for elderly patients with head and neck cancer. Anticancer Drugs. 2011;22(27):647–655. - PubMed
    1. Hartl DM, Ferlito A, Brasnu DM, et al. Evidence-based review of treatment options for patients with glottic cancer. Head & Neck. 2011;33(11):1638–1648. - PubMed
    1. Chone CT, Yonehara E, Martins JEF, Altemani A, Crespo AN. Importance of anterior commissure in recurrence of early glottic cancer after laser endoscopic resection. Archives of Otolaryngology—Head and Neck Surgery. 2007;133(9):882–887. - PubMed
    1. Allegra E, Franco T, Trapasso S, Domanico R, La Boria A, Garozzo A. Modified supracricoid laryngectomy: oncological and functional outcomes in the elderly. Clinical Interventions in Aging. 2012;7:475–480. - PMC - PubMed
    1. Garozzo A, Allegra E, La Boria A, Lombardo N. Modified supracricoid laryngectomy. Otolaryngology—Head and Neck Surgery. 2010;142(1):137–139. - PubMed

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