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Review
. 2014 Nov;30(6):596-602.
doi: 10.1097/MOG.0000000000000115.

Management of gastric cancer

Geoffrey Y Ku  1 , David H Ilson
Affiliations
Review

Management of gastric cancer

Geoffrey Y Ku et al. Curr Opin Gastroenterol. 2014 Nov.

Abstract

Purpose of review: Gastric cancer is an uncommon cancer in the United States but is a very common cancer globally and is endemic in East Asia. It is a virulent cancer that presents with metastatic disease in about one half of United States patients.

Recent findings: In this review article, we discuss palliative chemotherapy options as well as validated preoperative, perioperative and postoperative strategies for locally advanced disease, which include chemotherapy and/or chemoradiation.

Summary: In the metastatic setting, there has been incremental improvement in cytotoxic chemotherapy combinations in the past 2 decades. Two targeted agents - trastuzumab and ramucirumab - are now approved. In the locally advanced setting, perioperative chemotherapy or postoperative chemotherapy or chemoradiation improves outcomes relative to surgery alone.

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