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Review
. 2014 Dec;12(4):433-8.
doi: 10.1007/s11914-014-0235-y.

Aerobic glycolysis in osteoblasts

Emel Esen  1 , Fanxin Long
Affiliations
Review

Aerobic glycolysis in osteoblasts

Emel Esen et al. Curr Osteoporos Rep. 2014 Dec.

Abstract

Osteoblasts, the chief bone-making cells in the body, are a focus of osteoporosis research. Although teriparatide, a synthetic fragment of the human parathyroid hormone (PTH), has been an effective bone anabolic drug, there remains a clinical need for additional therapeutics that safely stimulates osteoblast number and function. Work in the past several decades has provided unprecedented clarity about the roles of growth factors and transcription factors in regulating osteoblast differentiation and activity, but whether these factors may regulate cellular metabolism to influence cell fate and function has been largely unexplored. The past few years have witnessed a resurgence of interest in the cellular metabolism of osteoblasts, with the hope that elucidation of their metabolic profile may open new avenues for developing bone anabolic agents. Here we review the current understanding about glucose metabolism in osteoblasts.

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Conflict of interest statement

Conflict of Interest

E Esen and F Long both declare no conflicts of interest.

Figures

Figure 1
Figure 1. Metabolic fates of glucose in mammalian cells
G6PDH: Glucose-6-phosphate dehydrogenase. GFAT: Glutamine fructose-6-phosphate amidotransferase. PDH: Pyruvate dehydrogenase complex.
See this image and copyright information in PMC

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