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. 2014 Sep;34(9):5091-8.

A dosimetric analysis of intensity-modulated radiation therapy with bone marrow sparing for cervical cancer

Naoya Murakami  1 , Hiroyuki Okamoto  2 , Takahiro Kasamatsu  3 , Kazuma Kobayashi  2 , Ken Harada  2 , Mayuka Kitaguchi  2 , Shuhei Sekii  2 , Kana Takahashi  2 , Kotaro Yoshio  2 , Koji Inaba  2 , Madoka Morota  2 , Minako Sumi  2 , Takafumi Toita  4 , Yoshinori Ito  2 , Jun Itami  2
Affiliations
  • PMID: 25202097

A dosimetric analysis of intensity-modulated radiation therapy with bone marrow sparing for cervical cancer

Naoya Murakami et al. Anticancer Res. 2014 Sep.

Abstract

Background/aim: The purpose of the present study was to compare intensity-modulated radiation therapy (IMRT) plan with (Bone Marrow Sparing (BMS) - IMRT) or without (normal-IMRT) an intention of avoiding bone marrow in order to minimize treatment-related toxicity.

Patients and methods: Computed tomography (CT) images of 10 consecutive postoperative cervical cancer patients were used. All patients were already treated by normal-IMRT. BMS-IMRTs were created for this study and dose-volume histogram parameters were compared.

Results: Both planning target volume (PTV) D95% and D97% were statistically lower in BMS-IMRT than normal-IMRT, however, the difference was lower than 3%. There were no statistical differences between BMS-IMRT and normal-IMRT in the mean value of rectum V30Gy, V50Gy; bladder V45Gy, V50Gy; Bowel V35Gy, and V50Gy. Both in whole pelvic bone (WPB) and inner cavity of pelvic bone (ICPB), the mean value of V10Gy, V30Gy, and V40Gy of BMS-IMRT were statistically lower than that of normal-IMRT.

Conclusion: Both lower and higher dose for WPB as well as ICPB were effectively lowered by BMS-IMRT.

Keywords: Cervical cancer; IMRT; bone marrow sparing; postoperative radiation therapy; radical hysterectomy.

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