Sildenafil citrate in fetal growth restriction
- PMID: 25202677
- PMCID: PMC4138426
Sildenafil citrate in fetal growth restriction
Abstract
Background: Pregnancies with early onset fetal growth restriction have poor perinatal outcome. Sildenafil citrate (PDE -5 inhibitor) as a vasodilator increases utero-placental blood flow and potentiates fetal growth.
Case presentation: In this study, a case was examined and Sildenafil was administered for her. It was found that Sildenafil improved the uterine blood flow with a favorable fetal outcome at delivery.
Conclusion: Sildenafil, as a vasodilator has emerged as a potential management option in the treatment of Intra Uterine Growth Retardation (IUGR) and preeclampsia by later normalization in velocimetric profile.
Keywords: Fetal growth restriction; Pregnancy; Sildenafil citrate.
References
-
- Soregaroli M, Valcamonico A, Scalvi L, Danti L, Frusca T. Late normalisation of uterine artery velocimetry in high risk pregnancy. Eur J Obstet Gynecol Reprod Biol. 2001;95(1):42–5. - PubMed
-
- Zoma WD, Baker RS, Clark KE. Effects of combined use of sildenafil citrate (Viagra) and 17beta-estradiol on ovine coronary and uterine hemodynamics. Am J Obstet Gynecol. 2004;190(5):1291–7. - PubMed
-
- Wareing M, Myers JE, O'Hara M, Kenny LC, Taggart MJ, Skillern L, et al. Phosphodiesterase-5 inhibitors and omental and placental small artery function in normal pregnancy and pre-eclampsia. Eur J Obstet Gynecol Reprod Biol. 2006;127(1):41–9. - PubMed
-
- Wareing M, Myers JE, O'Hara M, Baker PN. Silde-nafil citrate (Viagra) enhances vasodilatation in fetal growth restriction. J Clin Endocrinol Metab. 2005;90(5):2550–5. - PubMed
-
- Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phospho-diesterase isozymes. J Urol. 1998;159(6):2164–71. - PubMed
Publication types
LinkOut - more resources
Full Text Sources