Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2014:2014:926932.
doi: 10.1155/2014/926932. Epub 2014 Aug 19.

Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and meta-analysis

Jie Xu  1 , Yan Hong Zhao  2 , Yun Ping Chen  1 , Xiao Lei Yuan  3 , Jiao Wang  1 , Hui Zhu  1 , Chun Mei Lu  1
Affiliations
Meta-Analysis

Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and meta-analysis

Jie Xu et al. ScientificWorldJournal. 2014.

Abstract

Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications. Inflammation may play a role in the pathogenesis of GDM. We performed a systematic review and meta-analysis to determine whether maternal serum concentration of tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin were associated with GDM. A systematic search of PubMed and Medline was undertaken. In total, 27 trials were evaluated by meta-analyses using the software Review Manager 5.0. The results showed that maternal TNF-α (P = 0.0003) and leptin (P < 0.00001) concentrations were significantly higher in GDM patients versus controls. However, maternal adiponectin (P < 0.00001) concentration was significantly lower in GDM patients compared with controls. Subgroup analysis taking in consideration the effect of obesity on maternal adipokine levels showed that circulating levels of TNF-α and leptin remained elevated in GDM patients compared to their body mass index (BMI) matched controls, and adiponectin level remained depressed in GDM individuals. Our findings strengthen the clinical evidence that GDM is accompanied by exaggerated inflammatory responses.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow diagram of the selection and systematic review of studies.
Figure 2
Figure 2
Mean difference (MD) and 95% CI of individual studies and pooled data for the association of maternal concentration of TNF-α with GDM risk. Positive values denote higher in GDM patients; negative values denote higher in healthy control subjects.
Figure 3
Figure 3
Mean difference (MD) and 95% CI of individual studies and pooled data for the association of maternal concentration of leptin with GDM risk. Positive values denote higher in GDM patients; negative values denote higher in healthy control subjects.
Figure 4
Figure 4
Mean difference (MD) and 95% CI of individual studies and pooled data for the association of maternal concentration of adiponectin with GDM risk. Positive values denote higher in GDM patients; negative values denote higher in healthy control subjects.
See this image and copyright information in PMC

References

    1. Gabbe SG. Gestational diabetes mellitus. The New England Journal of Medicine. 1986;315(16):1025–1026. - PubMed
    1. Metzger BE, Buchanan TA, Coustan DR, et al. Summary and recommendations of the fifth international workshop-conference on gestational diabetes mellitus. Diabetes Care. 2007;30(supplement 2):S251–S260. - PubMed
    1. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860–867. - PubMed
    1. Kirwan JP, Hauguel-de Mouzon S, Lepercq J, et al. TNF-α is a predictor of insulin resistance in human pregnancy. Diabetes. 2002;51(7):2207–2213. - PubMed
    1. Lepercq J, Cauzac M, Lahlou N, et al. Overexpression of placental leptin in diabetic pregnancy: a critical role for insulin. Diabetes. 1998;47(5):847–850. - PubMed

LinkOut - more resources