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Review
. 2014 Dec;12(4):428-32.
doi: 10.1007/s11914-014-0236-x.

Osteoblasts: a novel source of erythropoietin

Colleen Wu  1 , Amato J Giaccia, Erinn B Rankin
Affiliations
Review

Osteoblasts: a novel source of erythropoietin

Colleen Wu et al. Curr Osteoporos Rep. 2014 Dec.

Abstract

Osteoblasts are an important cellular component of the bone microenvironment controlling bone formation and hematopoiesis. Understanding the cellular and molecular mechanisms by which osteoblasts regulate these processes is a rapidly growing area of research given the important implications for bone therapy, regenerative medicine, and hematopoietic stem cell transplantation. Here we summarize our current knowledge regarding the cellular and molecular crosstalk driving bone formation and hematopoiesis and will discuss the implications of a recent finding demonstrating that osteoblasts are a cellular source of erythropoietin .

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Conflict of interest statement

Conflict of Interest C. Wu, A. J. Giaccia, and E. B. Rankin declare that they have no conflicts of interest.

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