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Review
. 2014 Jul;21(3):112-4.
doi: 10.5214/ans.0972.7531.210308.

The mechanism of degeneration of striatal neuronal subtypes in Huntington disease

Azadeh A Rikani  1 , Zia Choudhry  2 , Adnan M Choudhry  3 , Nasir Rizvi  4 , Huma Ikram  5 , Nusrat J Mobassarah  6 , Sagun Tulli  7
Affiliations
Review

The mechanism of degeneration of striatal neuronal subtypes in Huntington disease

Azadeh A Rikani et al. Ann Neurosci. 2014 Jul.

Abstract

The pattern of neurodegeneration in Huntington's disease (HD) is very characteristic of regional locations as well as that of neuronal types in striatum. The different striatal neuronal populations demonstrate different degree of degeneration in response to various pathological events in HD. In the striatum, medium spiny GABA neurons (MSN) are preferentially degenerate while others are relatively spared. Vulnerability of specific neuronal populations within the striatum to pathological events constitutes an important hallmark of degeneration in HD. In an attempt to explain a likely mechanism of degeneration of striatal neuronal populations in HD, possible causes underlying differential vulnerability of neuronal subtypes to excitoxic insults and neurotrophic factors are discussed in this paper.

Keywords: Huntington's Disease; MSN; NMDA.

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Figures

Fig. 1:
Fig. 1:
Regulation of NGF mRNA levels by glutamate receptor agonists. Intrastriatal QUIN injection induced a continuous increase of NGF mRNA from 24 h until the last time examined (A). Increased levels of NGF mRNA were also observed 6 h after AMPA intrastriatal injury (C). No changes in NGF mRNA levels were obtained in KA- (B) or ACPD- (D) injected striatal. Triangles represent shaminjected striatal, whereas circle represent results from EAA injection. Values are represented as mean 6 SEM (*P, 0.05). Neurobiology of Disease 5, 357–364 (1998).
See this image and copyright information in PMC

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