Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Apr 1;9(7):677-83.
doi: 10.4103/1673-5374.131564.

Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury

Jonghyuck Park  1 , Breanne Muratori  2 , Riyi Shi  1
Affiliations

Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury

Jonghyuck Park et al. Neural Regen Res. .

Abstract

IN THE HOURS TO WEEKS FOLLOWING TRAUMATIC SPINAL CORD INJURIES (SCI), BIOCHEMICAL PROCESSES ARE INITIATED THAT FURTHER DAMAGE THE TISSUE WITHIN AND SURROUNDING THE INITIAL INJURY SITE: a process termed secondary injury. Acrolein, a highly reactive unsaturated aldehyde, has been shown to play a major role in the secondary injury by contributing significantly to both motor and sensory deficits. In particular, efforts have been made to elucidate the mechanisms of acrolein-mediated damage at the cellular level and the resulting paralysis and neuropathic pain. In this review, we will highlight the recent developments in the understanding of the mechanisms of acrolein in motor and sensory dysfunction in animal models of SCI. We will also discuss the therapeutic benefits of using acrolein scavengers to attenuate acrolein-mediated neuronal damage following SCI.

Keywords: 3-hydrxypropyl mercapturic acid; acrolein-lysine adduct; hydralazine; oxidative stress; spinal cord injury.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Chemical structures of acrolein scavengers, hydralazine, dihydralazine, and phenelzine (left to right).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Adams JD, Jr, Klaidman LK. Acrolein-induced oxygen radical formation. Free Radic Biol Med. 1993;15:187–193. - PubMed
    1. Andrade EL, Meotti FC, Calixto JB. TRPA1 antagonists as potential analgesic drugs. Pharmacol Ther. 2012;133:189–204. - PubMed
    1. Azbill RD, Mu X, Bruce-Keller AJ, Mattson MP, Springer JE. Impaired mitochondrial function oxidative stress and altered, antioxidant enzyme activities following traumatic spinal cord injury. Brain Res. 1997;765:283–290. - PubMed
    1. Basso DM, Beattie MS, Bresnahan JC. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol. 1996;139:244–256. - PubMed
    1. Borgens RB, Liu-Snyder P. Understanding secondary injury. Q Rev Biol. 2012;87:89–127. - PubMed

LinkOut - more resources