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. 2014 Apr 1;9(7):677-83.
doi: 10.4103/1673-5374.131564.

Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury

Jonghyuck Park  1 , Breanne Muratori  2 , Riyi Shi  1
Affiliations

Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury

Jonghyuck Park et al. Neural Regen Res. .

Abstract

IN THE HOURS TO WEEKS FOLLOWING TRAUMATIC SPINAL CORD INJURIES (SCI), BIOCHEMICAL PROCESSES ARE INITIATED THAT FURTHER DAMAGE THE TISSUE WITHIN AND SURROUNDING THE INITIAL INJURY SITE: a process termed secondary injury. Acrolein, a highly reactive unsaturated aldehyde, has been shown to play a major role in the secondary injury by contributing significantly to both motor and sensory deficits. In particular, efforts have been made to elucidate the mechanisms of acrolein-mediated damage at the cellular level and the resulting paralysis and neuropathic pain. In this review, we will highlight the recent developments in the understanding of the mechanisms of acrolein in motor and sensory dysfunction in animal models of SCI. We will also discuss the therapeutic benefits of using acrolein scavengers to attenuate acrolein-mediated neuronal damage following SCI.

Keywords: 3-hydrxypropyl mercapturic acid; acrolein-lysine adduct; hydralazine; oxidative stress; spinal cord injury.

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Figures

Figure 1
Figure 1
Chemical structures of acrolein scavengers, hydralazine, dihydralazine, and phenelzine (left to right).
See this image and copyright information in PMC

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