Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Apr 1;9(7):763-5.
doi: 10.4103/1673-5374.131586.

The metabolic brain network in patients with Parkinson's disease based on (18)F-FDG PET imaging: evaluation of neuronal injury and regeneration

Jingjie Ge  1 , Ping Wu  1 , Chuantao Zuo  1
Affiliations

The metabolic brain network in patients with Parkinson's disease based on (18)F-FDG PET imaging: evaluation of neuronal injury and regeneration

Jingjie Ge et al. Neural Regen Res. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest: None declared.

Figures

Figure 1
Figure 1
PD-related spatial covariance pattern. (A) Parkinson's disease (PD)-related pattern (PDRP) identified by network analysis of 18F-FDG PET scans from PD patients and age-matched normal controls. This spatial covariance pattern was characterized by metabolic increases in the pallidum, thalamus, pons, and cerebellum, associated with decreases in the premotor and posteriorparietal-occipital areas. Cerebral regions with metabolic increases are color coded from red to yellow, while those with metabolic decreases are color coded from blue to purple. (B) PDRP expression (subject scores) was increased in patients with PD relative to the normal subjects. P value was assessed by independent two sample t-test and differences in PDRP scores between two groups reached significance (P < 0.001). (C) Correlations between PDRP expression and clinical indicators of disease severity in PD. Subject scores in individual patients presented significant correlation with the Unified Parkinson's Disease Rating Scale motor ratings (UPDRS).
Figure 2
Figure 2
MSA-related spatial covariance pattern. Multiple system atrophy (MSA)-related pattern (MSARP) identified by network analysis of 18F-FDG PET scans from MSA patients and age-matched normal controls. This pattern was characterized by metabolic decreases in the putamen and the cerebellum. Cerebral regions with metabolic metabolic decreases are color coded from blue to purple.
Figure 3
Figure 3
PSP-related spatial covariance pattern. Progressive supranuclear palsy (PSP)-related pattern (PSPRP) identified by network analysis of 18F-FDG PET scans from PSP patients and age-matched normal controls. This pattern was characterized by metabolic decreases in the medial prefrontal cortex, ventro lateral prefrontal cortex (VLPFC), caudate nuclei, medial thalamus and the upper brainstem putamen. Cerebral regions with metabolic metabolic decreases are color coded from blue to purple
Figure 4
Figure 4
Comparison of abnormal cerebral metabolic regions in patients with mild and severe Parkinson's disease (PD). In patients with early PD, cerebral hypermetabolism was detected in the thalamus, lentiform nucleus and cerebellum, while hypometaboIism was not observed in any subregions. In those with advanced PD, the hypermetabolism was also found in the thalamus, lentiformnucleus and cerebellum, with a higher magnitude in glucose metabolism rate. Meanwhile, hypometabolism was observed in bilateral parietal lobules. Cerebral regions with metabolic increases are color coded from red to yellow, while those with metabolic decreases are color coded from blue to purple.
See this image and copyright information in PMC

References

    1. Asanuma K, Tang C, Ma Y, Dhawan V, Mattis P, Edwards C, Kaplitt MG, Feigin A, Eidelberg D. Network modulation in the treatment of Parkinson's disease. Brain. 2006;129:2667–2678. - PMC - PubMed
    1. Bhidayasiri R, Reichmann H. Different diagnostic criteria for Parkinson disease: what are the pitfalls? J Neural Transm. 2013;120:619–625. - PubMed
    1. Eckert T, Barnes A, Dhawan V, Frucht S, Gordon MF, Feigin AS, Eidelberg D. FDG PET in the differential diagnosis of parkinsonian disorders. Neuroimage. 2005;26:912–921. - PubMed
    1. Eckert T, Tang C, Ma Y, Brown N, Lin T, Frucht S, Feigin A, Eidelberg D. Abnormal metabolic networks in atypical parkinsonism. Mov Disord. 2008;23:727–733. - PubMed
    1. Eidelberg D, Moeller JR, Dhawan V, Spetsieris P, Takikawa S, Ishikawa T, Chaly T, Robeson W, Margouleff D, Przedborski S, Et A. The metabolic topography of parkinsonism. J Cereb Blood Flow Metab. 2008;14:783–801. - PubMed

LinkOut - more resources