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. 2014 Jul;5(3):193-6.
doi: 10.4103/0976-500X.136101.

Effects of glucocorticoids and tumor necrosis factor-alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis

Raffaele Serra  1 , Raffaele Grande  1 , Gianluca Buffone  1 , Edoardo Scarcello  2 , Fabio Tripodi  3 , Pierandrea Rende  4 , Luca Gallelli  4 , Stefano de Franciscis  1
Affiliations

Effects of glucocorticoids and tumor necrosis factor-alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis

Raffaele Serra et al. J Pharmacol Pharmacother. 2014 Jul.

Abstract

Objective: To explore the effect of sequential treatment with glucocorticoid and tumor necrosis factor-alpha inhibitors in patients with Takayasu arteritis (TA).

Materials and methods: In five patients with TA, the effects of the sequential treatment with prednisone for 5-7 months and then with adalimumab (ADA) + methotrexate (MTX) or infliximab + MTX, or with ADA only, for 12 months on both clinical and laboratory findings were evaluated.

Results: All treatments improved both symptoms and laboratory parameters without the development of side-effects.

Conclusions: It was hypothesized that MMP-9 and neutrophil gelatinase-associated lipocalin could be markers of the response to the treatments.

Keywords: Adalimumab; infliximab; matrix metalloproteinases-9; methotrexate; neutrophil gelatinase-associated lipocalin; takayasu arteritis.

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Conflict of interest statement

Conflict of Interest: None declared.

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