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Comment
. 2014 Sep 10;16(3):269-71.
doi: 10.1016/j.chom.2014.08.011.

Flavivirus NS5 Prevents the InSTATement of IFN

Pei-Yong Shi  1
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Free article
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Flavivirus NS5 Prevents the InSTATement of IFN

Pei-Yong Shi. Cell Host Microbe. .
Free article

Abstract

Given the potency of interferon-α/β, viral evasion of this pathway is crucial for infection. In this issue of Cell Host & Microbe, Laurent-Rolle et al. (2014) report that during yellow fever virus infection, interferon-α/β stimulates the polyubiquitination of viral NS5, which binds to STAT2 and inhibits transcription of interferon-stimulated genes.

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