Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jan;108(1):183-90.
doi: 10.1083/jcb.108.1.183.

Integrin phosphorylation is modulated during the differentiation of F-9 teratocarcinoma stem cells

S C Dahl  1 , L B Grabel
Affiliations

Integrin phosphorylation is modulated during the differentiation of F-9 teratocarcinoma stem cells

S C Dahl et al. J Cell Biol. 1989 Jan.

Abstract

The retinoic acid-induced differentiation of F-9 teratocarcinoma cells in monolayer culture is accompanied by the accumulation of fibrillar fibronectin deposits, the appearance of a highly structured actin cytoskeleton, and the redistribution of integrin to apparent sites of substrate contact. We have studied the 140-kD fibronectin receptor during this process and report that although the integrin molecule is present in equivalent amounts before and after differentiation, the level of integrin phosphorylation decreases dramatically as the cells differentiate. This loss of phosphorylation coincides temporally with the observed changes in actin, fibronectin, and integrin organization. The phosphorylation state of integrin thus may mediate developmentally regulated cell-matrix interactions.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1976 Jun;73(6):2047-51 - PubMed
    1. Cell. 1978 Oct;15(2):393-403 - PubMed
    1. Cell. 1978 Nov;15(3):875-86 - PubMed
    1. J Biol Chem. 1979 Jun 25;254(12):5475-82 - PubMed
    1. Cell. 1979 Mar;16(3):675-85 - PubMed

Publication types